Biodegradable Polymeric Pharmaceutical Nanoemulgel Coloaded with Eucalyptol-Lornoxicam: Fabrication and Characterizations for Possible Better Pain Management

Nanoemulgels are considered as potential and ideal drug delivery systems for the transdermal administration of poorly soluble drugs like lornoxicam. Their intrinsic characteristics, such small globule size well excipient type, make passage easier. The current study was aimed at developing nanoemulgel based formulation lornoxicam coloaded with eucalyptol to enhance skin permeation bioavailability in order promote therapeutic outcome appropriate time. High shear homogenization technique utilized develop optimized encapsulated nanoemulsion followed by its conversion into addition 1% Carbopol 940 gelling agent. Different characterization tests were performed on surface charge, particle distribution, viscosity, spreadability, pH, content determination, entrapment efficiency, vitro release, analysis. had 143.7 ± 2.18 nm. results penetration experiments found satisfactory. Based permeability parameters constant (Kp), enhancement ratio (Er), steady state flux (Jss) revealed greater values satisfactory outcomes. When compared other formulations (LRX EU nanoemulgel), LRX-EU produced improved profile (flux, id="M2"> 189.63 7.68 μg/cm2/h; coefficient, id="M3"> 2.09 0.067 cm/h; ER, 4.274). This work clearly proved that could be developed generate stable systems. Thus, NEG seems promising terms physicochemical properties, enhanced bioavailability, high LRX formulation.